Ketosis is a metabolic state which is marked by an increase in the levels of the ketone bodies in tissues. This is pathological in conditions like diabetes mellitus. Concentration of ketone bodies within the body tissues varies owing to various factors. Ketogenesis, on the other hand, is the biochemical process of formation of ketone bodies. Utilization of ketone bodies alongside the fate of ketone bodies is crucial.

Lecture Duration – 00:47:35
Release Date – June 2019

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Ketone bodies are the main highlight of this section. A range of concepts have been discussed here. From ketosis and inter-relationship of acetone, acetoacetate and beta-OH butyric acid to various terminologies. Additionally, ketoacidosis and ketonaemia are defined. Moreover, ketonuria alongside ketosis is comprehensively explained.

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Ketogenesis is defined as a biochemical process by which living organisms synthesize ketone bodies via enzymes. This process initially involves the formation of acetoacetate by diacylation or second pathway. In addition to this, formation of acetone and beta-OH-butyrate is extensively elaborated.

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Extrahepatic tissues utilize ketone bodies as fuel via a process termed as ketolysis. Also, activation of acetoacetate along with the second mechanism and fate of beta-OH-butyrate are elucidated. Furthermore, fate of ketones in conjunction with the susceptibility to ketosis has been explicated.

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