Professor Gavin Giovannoni suggests ketogenic diet and intermittent fasting could be beneficial in MS, but is he right? In this video, I review the theoretical mechanisms by which ketosis could improve mitochondrial health in MS and show the relevant animal and human studies.
Myla Goldman’s pilot ketogenic diet study: https://nn.neurology.org/content/6/4/e565.long
Randomized trial of ketogenic diet or intermittent fasting: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941322/
Review of 3 studies on calorie restriction by Mowry: https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S221103482030225X?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS221103482030225X%3Fshowall%3Dtrue&referrer=https:%2F%2Fpubmed.ncbi.nlm.nih.gov%2F
Professor Gavin Giovannoni’s commentary on diet: https://multiple-sclerosis-research.org/2020/10/dietspeak-is-there-an-ideal-ms-diet/
Potential mechanism of a ketogenic diet in multiple sclerosis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709725/
Fasting-mimicking diet and ketogenic diet on quality of life in MS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899145/
Images on ketogenic diet metabolism: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494562/
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A Randomized, Double-Blind Trial of Nystatin Therapy for the Candidiasis Hypersensitivity Syndrome: https://www.nejm.org/doi/full/10.1056…
Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual’s medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.