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Special Thanks to my team and Nicholas Norwitz – Oxford PhD Researcher and Harvard Med Student – for working diligently on research as well!

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There could be a ton of various reasons as to why you’ve hit a weight loss plateau. So in in this video, we will go over 9 MAIN REASONS YOUR WEIGHT LOSS IS STALLING! So, Let’s dive in and I’ll see you in the COMMENTS!!

Too Much Fat (especially before bed)

Some people greatly increase their fat intake and think it’ll speed up the fat burning processes, not knowing that fatty acid release is regulated

bHB can activate hydroxycarboxylic Acid Receptor 2 (HCAR2), a Protein Coding gene – among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway

HCAR2 activation by bHB (or other ligands) reduces lipolysis in adipocytes

Too Much Snacking

Regardless of the food you eat, there will be a hit, or elevation of some extent, on insulin – insulin inhibits hormone-sensitive lipase (HSL), hindering fatty acid mobilization

No Periodic Low Fat Periods

Upregulates when fatty acids liberated from tissue
Activates UCP (browning of white fat)

Fasting and PPAR-a

PPARα increases the expression of several genes, including those involved in lipid transport, β-oxidation, lipoprotein uptake, etc. Specifically, PPARα increases the expression of the fat transporter protein CD36 and uncoupling (fat-browning) protein UCP-2 to increase fat burning

Not Enough Veggies (Butyrate)

One paper all the way back from 1962 that showed how the (rat) liver can turn butyrate into beta-hydroxybutyrate (from here on, BHB), published in the Biochemical Journal. However, for the most part, and for practical purposes, it’s best to think of butyrate and BHB as separate.

The Journal of Functional Foods, 2017:

Butyrate is also a signaling molecule:

Induces the secretion of glucagon-like peptide 1, improving insulin sensitivity.
Increases BDNF levels, promoting neuronal growth and health in the brain.
Inhibits histone deacetylases (HDACs) to change gene expression.
Inhibits NFkB and activates regulatory T-cells to decrease inflammation.
Induces fibroblast growth factor 21 (FGF21) to increase beta-oxidation

Crossing the threshold of Carbs Just Barely

Results in blood sugar spikes

Focusing on Measuring Levels

Food increases the liver concentration of malonyl-CoA, inhibits carnitine acyltransferase I and reverses the fatty acid oxidation process

Inflammatory Foods (LPS related)

A lipopolysaccharide (LPS) is a molecule present on bacterial membranes. Our gut is full of bacteria with LPS but the mucous is preventing their contact with the gut lining.

However, the western diet is associated with higher gut permeability, decreased mucus production and therefore LPS can get into the bloodstream where it triggers a response.

If the gut barrier integrity is compromised continuously, LPSs are constantly leaking to the bloodstream and cause the low-grade inflammation.

Working Out on Full Stomach or with BCAAs in your System

Full Stomach

Study – British Journal of Nutrition



Stress (any stress) causes the release of cortisol. Cortisol raises blood sugar as part of the “fight or flight” response and, consequently, increases insulin. Insulin kicks you out of ketosis.

For an experimental example, in a study from the American Journal of Hypertension, researchers gave 6 male volunteers cortisol, 50 mg orally four times daily, for 5 days – insulin levels rose 36% from baseline.

Nicholas Norwitz – Oxford PhD Researcher and Harvard Med Student: